Product Information
Manufactured by:
Istituto Ganassini S.p.A.
di Ricerche Biochimiche
Milano, Italy.
ACTIVE INGREDIENTS
Beta Glucan (5% Plerasan™)
Beta glucans are
naturally occurring polysaccharides found on the cell wall of certain fungi
(mushrooms, yeast) and oats. Beta glucan is one of the most potent
immunostimulatory agents, with its action at the dermal level mediated by
activating the innate immune response (complement, macrophages, neutrophils, natural
killer cells). Documented evidence shows that macrophages plays a key role in
facilitating wound healing process due its wound debridement, cell migration,
cytokine release, angiogenesis, matrix synthesis regulation and antimicrobial
actions. With beta glucan main mechanism of action as an immunostimulatory agent
via the activation of macrophages and migration of neutrophils, the inclusion
of beta glucan in Neoviderm contributes significantly to the regeneration,
soothing and healing process.
Publications:
Gu YH, Takagi Y, et
al; Enhancement of radioprotection and anti-tumor immunity by yeast-derived
beta-glucan in mice, J Med Food. 8(2) 154-8. 2005
Patchen M.L.,
MacVittie T, Jackson W; “Postirradiation glucan administration
enhances the radioprotective effects of WR-2721. Radiat. Res.
117:59-69. 1989
Patchen Ml, Chirigos
MA, Brook I, Use of glucan and other immunopharmacological agents in the prevention
and treatment of acute radiation injuries, Fundam Appl Toxicol,
11(4):573-4. AFRRI, Nov 1988.
Patchen M.L.,
D’Alesandro M.M., Brook I., Blakely W.F. McVittie T.J.; Glucan: Mechanisms Involved
in Its ‘Radioprotective’ Effect. J Leuc Biol.; 42:95-105. 1987.
Pachen ML, MacVittie
TJ, Comparative effects of soluble and particulate glucans on survival in
irradiated mice, J Biol Response Mod 5(1):45-60. 1986.
Toklu HZ, Sener G, Beta-glucan
protects against burn-induced oxidative organ damage in rats, Int.
Immunopharmacol; 6(2):156-6. 2006.
Browder I.W.,
DiLuzio N.R., et al. Enhanced Healing of Decubitus Ulcers by
Topical Application of Particulate Glucan. Tulane University School
of Medicine; Research Summary. 1984.
Sener
G, Sert G, Ozer SA, Arbak S, Uslu B, Gedik N, Avanoglu-Dulger G; Pressure
ulcer-induced oxidative organ injury is ameliorated by beta-glucan treatment in
rats. Int Immunopharmacol:6(5):724-32. 2006.
Leibovich S.J., et
al., Promotion of Wound Repair in Mice by Application of Glucan.
J. Reticuloendothel, Soc. 27: 1-11. 1980
Williams D.L.
,Mueller A., Mueller P., Swails W., et. al., Randomized phase I/II trial of a macrophage-specific immunomodulator
(PGG-glucan) in high-risk surgical patients. Ann. Surg.;
220(5):601-609. 1994.
Wolk, M. and Danon,
D.; Promotion of Wound Healing by Yeast Glucan Evaluated on Single Animals;
Medical Biology; 63:73-80. 1985.
Aliginates are
widely used in the management of wound healing. The inclusion of Sodium
Alginate and TEA Alginate in Neoviderm keeps the skin environment humid,
moisturized at a steady temperature, formation of granulation tissues and
absorbs eventual exudates. Alginates are
highly absorbent and act to provide a moist environment that supports the
healing of the skin. Hydrates and keep moist. Limits wound secretion and
bacterial contamination.
Hyaluronic Acid
A key component of the outer skin matrix, hyaluronic acid, a class of glucose-based glycan, helps maintain the skin integrity by retaining moisture, contributing to skin resilience and suppleness. Hyaluronic acid triggers the early stages of wound healing and provides the perfectly moist environment to facilitate the process. Studies have shown hyaluronic acid ability to reduce the incidence of high grade dermatitis, leading to increasing patient compliance and quality of life. The addition of hyaluronic acid in Neoviderm provides a protective action to the skin by forming a moisture protectant on the surface of the skin, and with its ability to reduce the trans-epidermal water loss, intensely moisturizes and hydrates the skin and rapidly
Publications:
Liguori V, Guillemin C, Pesce GF, Mirimanoff RO, Bernier J. Double-blind, randomized clinical study comparing hyaluronic acid cream
to placebo in patients treated with radiotherapy. Radiother Oncol. 1997 Feb;42(2):155-61.
Department of Radio-Oncology, Ospedale
San Giovanni, Bellinzona, Switzerland.
Price
RD, Myers
S, Leigh
IM, Navsaria
HA.
The role of hyaluronic acid in
wound healing: assessment of clinical evidence. Am J Clin Dermatol.
2005;6(6):393-402.
South Manchester University Hospitals NHS Trust, Manchester, UK.
Squalane
Squalane is a natural emollient and moisturize considered a biological hydrating agent that is closest to skin’s sebum. Squalane functions help to maintain and restores skin oil. The presence of squalane in Neoviderm functions to maintain and support the skin’s normal integrity by acting as an emollient and moisturizer, in particular to the horny layer of the epidermis.
Avocado Oil
Avocado oil is a natural
oil with a high trans-epidermal penetration capacity and acts by nourishing the
epidermal and dermal layers of the skin due its high emollient and moisturizing
properties. Due its high content of lipids, vitamin A, D and E, avocado oil
acts to relieve the skin barrier properties and relieves skin desquamation, a
key feature in treating dermatitis.
